Now you know the correct order of operations (see Maths in Order for a refresher), you can use it to solve problems with positive and negative numbers that have more than one operation.
Think: We need to simplify the problem by using our order of operation rules. Firstly, we perform any operations inside the brackets; division first followed by addition. Then we perform any other multiplication or division that is remaining, working from left to right.
Here's another example.
Think: Using our order of operations we want to first perform the subtraction in the brackets. We then want to evaluate the multiplication. Finally, we can subtract the product from $48$48.